The process of combining antibiotics increases the effectiveness and destructive power of the microbe and affects more than one type of microbes, such as neomycin and ampicillin.
The combination of antibiotics also helps prevent or reduce the growth of antibiotic-resistant microbial strains. Also, through this method, the microbe can be killed before it acquires resistance to antibiotics. An example of this is the confusion between kanamycin and amoxicillin.
It is preferable to combine several antibiotics sometimes in order to reduce the toxicity of each, such as combining several types of sulfa, This combination also helps reduce the ability of enzymes secreted by microbes to neutralize the effect of antibiotics, and this is what the penicillinase enzyme that breaks down ampicillin or amoxicillin did.
Disadvantages of combining antibiotics
In some cases, two antagonisms of some antibiotics occur, killing their effectiveness when combined, and this is what happens in the case of combining an antibacterial from the quinoline group and one of the nitrofuran compounds, because the antibacterial works during the growth of the microbe, while the antibiotic that stops the growth makes the microbe in a state of dormancy , Thus it does not affect it.
Also, the combination of some antibiotics without awareness of their properties and composition leads to an increase in their toxicity, and when escaping from this problem using a weak concentration, this leads to a problem, In many cases, antibiotics are used to treat some diseases. It results in side effects as a result of the treatment method and the type of preparation used, or because of the long period of use.
When using an antibiotic, some rules must be observed. The type of antibiotic must be renewed and its suitability for the purpose for which it is used, and whether it is fatal to bacteria or only inhibitor. Is absorbed from the intestine or has a local effect, The extent of its spectrum (wide or specific), intestinal or respiratory, and is it able to reach and give the appropriate concentration in the shortest time.
Also, if you need to give two antibiotics, Do they contradict or balance? It is noted that antibiotics succeed a lot in the face of bacterial cases, as for my infection is only secondary. Thus, it can be said that antibiotics are a double-edged sword, and a proper understanding of their modus operandi is the key to success.
Where antimicrobial strains are created, because the weak concentration does not kill the microbe, but also helps it to identify the chemical composition of the antibiotic, so it produces enzymes that break these antibiotics in the treatment of some microbes without adhering to some rules and controls, the most important of which is the care for the proper diagnosis of the disease, isolation of the microbe, identifying its properties and choosing Appropriate antibiotics, in addition to the need to use the correct doses of antibiotics for an appropriate period in order to achieve the desired goal of overcoming pathogenic microbes.